Researchers at the Mayo Clinic in the USA have discovered a new method of healing after a heart attack using stem cell therapy. Activated stem cells restored the heart muscle to its normal state before asystole. This also provided a blueprint for theHow stem cells work.
The new study shows that human cells in the heart probe damaged proteins to reverse complex changes caused by a heart attack. This type comes primarily from adult stem cells and bone marrow sources.
The magnitude of the change caused by a heart attack is sometimes too great. However, the heart could also repair itself or prevent further damage. Notably, however, stem cell therapy after heart attack completely or partially reversed two-thirds of these diseases, so that 85% of all cellular categories affected by disease responded positively to treatment. This is reported by Andre Terzic, Director of the Center for Regenerative Medicine. He is the lead author of the study.
This is a new understanding of how stem cells restore heart health. Furthermore, it could provide the framework for broader applications of stem cell therapy in various conditions.
The actual way in which stem cells work to repair a diseased organ is still poorly understood. This limits acceptance in clinical care. This study highlights the most comprehensive mechanisms for regeneration that form a plan for responsible and increasing action.
Heart disease is one of the most common causes of death. During a heart attack, heart tissue dies and weakens the heart. The diseased heart's response to stem cell treatment showed the development and growth of new blood vessels and new heart tissue.
Study results
The researchers compared thediseased heartsof laboratory mice that did not receive stem cell therapy after a heart attack with those that did. Using a scientific approach to map all the proteins in the heart muscle, the researchers identified 4,000 proteins. Of these, more than 10% were changed by a heart attack.
Scientists expected that stem cell therapy would lead to a beneficial result. However, they were surprised at how far this method shifted the condition of diseased hearts back to a healthy, pre-disease state. Such stem cells are being tested in advanced clinical studies on heart patients. The current findingsthis studywill enrich the knowledge base for stem cell therapies and may have the potential to guide future therapies.
