Herbs have long been used as folk remedies. Until now, many of the mechanisms underlying their action were unknown. In a new study, researchers examine how cilantro effectively inhibits certain seizures that are common in epilepsy and other diseases. The study published in the FASEB Journal explains the molecular effect of the medicinal herb (Coriandrum sativum) as a highly effective activator of potassium channels. This new discovery may lead to improvements in therapy and the development of more effective drugs.
“We discovered that coriander, used as a traditional anticonvulsant, activates a group of potassium channels in the brain to reduce seizure activity,” said Dr. Geoff Abbott, professor of physiology and biophysics at the UCI School of Medicine and leader of the study. "We found that a substance from coriander, called dodecenal, binds to a specific part of potassium channels to open them, thereby reducing cellular excitability."
The researchers examined the metabolites of coriander leaves and found that one - the long-chain fatty aldehyde (E)-2-dodecenal - activates multiple potassium channels, including the predominant neuronal isoform and the predominant cardiac isoform, which are responsible for regulating electrical activity in the heart and brain are responsible. This metabolite has also been found to be responsible for the herbal plant's anticonvulsant effects and inhibits certain chemically induced seizures. The results provide a basis for the plant's therapeutic effects and show that this ubiquitous culinary herb has a surprising influence on important potassium channels.
“In addition to antispasmodic properties, cilantro also has anticancer, anti-inflammatory and antibacterial properties,” Abbott said. “And best of all, it tastes good!”
The article was published on July 16, 2019 in EnglishTrade magazine “The FASEB Journal”published.
