Through sporting exercises, people not only train their muscles. You could also use sports as a treatment strategy for diabetes and fatty liver. This emerges from new research in which the authors showed the molecular adjustments of the liver mitochondria to be observed. Scientists from the German Center for Diabetes Research (DZD) and the Tübingen University Hospital carried out the study.
Could therapy for fatty liver use sport as an antidote?
Every fourth worldwide suffers from non -alcoholic liver disease. Those affected also often have type 2 diabetes and an increased risk of liver cirrhosis and cardiovascular diseases. In addition, non -alcoholic fat liver disease is associated with increased mortality. An imbalance between energy consumption and consumption is discussed as the cause of the disease. This leads to fat deposits in the liver and affects the function of the mitochondria over time. Both are risk factors for the development of hepatic insulin resistance and liver inflammation. To prevent and treat fat liver disease, the study authors therefore recommend changing lifestyle with increased physical activity. The researchers examined the extent to which regular movement changes the adaptation of the liver to an increased energy intake and what role the skeletal muscles play.
After the six -week intervention, the team examined the liver and muscles of mice for changes in the transcriptom, the mitochondrial proteoma, the lipid composition and the mitochondrial function. The results showed that at Fettleber Sport, important enzymes of glucose and fructose degradation and the mitochondrial metabolism regulate. In this way, the load on mitochondrial breathing and lipid synthesis can be reduced. As a rule, mitochondria are therefore also considered to be power plants in the cell. In addition, an increased breathing capacity of the skeletal muscles relieves the metabolic pollution in the liver. Accordingly, the study results also show that regular physical activity regulates many points of attack and at the same time important nodes of metabolic pathways. This is an effect that would not be accessible with monotherapy. The datathis studyoffer a comprehensive insight into the molecular adaptation of the liver and muscles to an energy -rich diet, training and combinatorial effects.
