According to a recent study, a single capsule as a combination therapy can prevent hypertension and cardiovascular disease more effectively than other treatments. The composition of aspirin and CSE inhibitorsthus reducing the risk of fatalitystroke or myocardial infarction by more than half. The new treatment strategy with combinations of very low doses in one pill led to a significant improvement in high blood pressure.
How a novel combination therapy can keep hypertension at bay
Researchers examined the new fixed-dose therapies both with and without aspirin compared to control groups in an analysis of more than 18,000 patients without prior heart disease from three large clinical trials. The therapeutic approach withAspirin reduced the risk of heart attacksand strokes by more than 50 percent. Traditionally, doctors start with one medication and then follow up to add or change treatment for high blood pressure. However, such strategies are often not successful in practice. The study authors observed the greatest effects of the approach with treatments that included antihypertensives, statins and aspirin. This was able to reduce fatal and non-fatal cardiovascular heart problems by about half. The benefits are consistent across different blood pressure levels, cholesterol levels, and with or without diabetes, although older people may benefit even more. The concept of a combination pill was first proposed as a strategy exactly 20 years ago.
The demonstration of a cost-effective approach using fixed-dose combinations is extraordinary and represents a major opportunity to combat heart disease more effectively worldwide. In addition, the new study results provide solid evidence that the new approach has great potential for a global treatment strategy. Although the comparison group used many more additional blood pressure medications during follow-up, they never caught up to four times the effect of the combination therapy. Additionally, since all components of the pill are generic and inexpensive, drug manufacturers can make them available to people at low cost.This studyshowed for the first time that this benefit can be sustained over the long term without diminishing over time.
