The new study with animal models has shown that the calorie -reduced diet is one of the most effective measures against age -related diseases. Although researchers know that individual cells are subject to many changes with increasing age of an organism, theRestriction of caloriesinfluence the processes such as cancer or diabetes. This results in opportunities that may also work with medication for the treatment of aging processes in humans.
Good reasons for calorie -reduced nutrition
So aging is the highest risk factor for many human diseases, including cancer, dementia, diabetes and metabolic syndrome. In the recently published study, the scientists compared laboratory meals, which recorded 30 percent fewer calories, with those who died normally. They checked the nutrition of the animals at the age of 18 months to 27 months. In humans, this would mean a reduced calorie diet aged around 50 to 70 years.
Many of the changes that then occurred when rats were older with normal diet did not occur when the calorie is restricted. Even in old age, many tissues and cells of animals with the calorie -reduced diet were very similar to those of young experimental animals. A total of 57 percent of the age -related changes in the cell composition, which occurred in their tissues with normal diet, did not exist in the case of calorie -reduced nutrition.
Some of the cells and genes that are most affected by the diet relate to immunity, inflammation and fat metabolism. The number of immune cells in almost every tissue examined increased dramatically with age. However, this has not changed in animals with impaired calories.
"The most important discovery in the current study is that the increase in inflammatory reaction is systematically opposed during aging by restricting calories." This is what the co -author jing qu. The mirrors of the transcription factor YBX1 have changed due to the food in 23 different cell types.
For this reason, the scientists believe that YBX1 could be an age -related transcription factor. They therefore plan further studies on its effects. The team is now trying to get the information from theStudyTo use to develop new medication and implement strategies to improve health.
