Researchers recently discovered a protein called BAM15 that can use medicine as a potential obesity treatment. The study results show that obesity and the associated diseases can be influenced. In addition, this offers the first proof that BAM15 acts as a coupler of energy and an effective medicationagainst weight gaincould be.
Possible obesity treatment in sight
Obesity affects millions of people worldwide and leads to health problems such as heart disease, diabetes and many types of cancer. The currently availableTherapy at obesityRarely achieves weight loss of more than 10 % and cannot offer patients long -term weight control. An alternative approach to reducing food intake is to reduce metabolic efficiency. Mitochondrial Protonophor tubs with small molecules reduce the mitochondrial coupling efficiency. This leads to increased nutrient oxidation to produce a certain amount of adenosine triphosphate (ATP). The study has shown that the mitochondrial decoupler has 2.4-dinitrophenol (DNP) in obese people in fatty people. However, DNP has a tight window between effective and toxic doses.
The protein BAM15 differs from the existing medication for weight reduction, which mainly acts by reducing the amount of food that eats a person or the calories that your body absorbs. In addition, it works by making the mitochondria, the cells of the cell, less efficient. The result is that the mitochondria consume more energy. This research represents a promising step in the discovery process. The scientists hope that BAM15 or related connections will advance the clinical development of drugs in the not too distant future. This could become a viable treatment option for patients with obesity. So you believe that BAM15 can not only be used for obesity treatment, but also for a number of health conditions. Among them also countDiabetes and fatty liver diseasesas well as some forms of cancer.
Research results
In the new study, the scientists from Pennington Biomedical in Los Angeles show for the first time that mice that BAM15 was administered are resistant to weight gain. There is also more calories than burning their untreated counterparts. Other advantages of BAM15 are the reduction in blood sugar and insulin levels, regardless of weight loss. It also improves the sensitivity of the skeletal muscle compared to the effects of insulin. The insulin resistance of the skeletal muscles is a main risk factor for theDevelopment of type 2 diabetes. Furthermore, the protein reduces the overall fat accumulation by preventing the fat in the liver, kidneys and blood. The accumulation of too much fat in these organs can damage them and lead to heart disease.
The researchers observed that BAM15 increased the breathing of the mitochondria and the persistent activity to a great extent. An improved regulation of body weight was observed together with a reduction in fat accumulation, improving the release of glucose in the entire body and energy consumption without changing body temperature. In contrast to usual medication for weight reduction, BAM15 does not reduce the amount of food absorbed, but made the mitochondria less efficient. The scientists have themStudypublished in the magazine Embo Molecular Medicine.
